Episode 6: Metabolic Dysfunction Explained | Sue Anne Part-2

In continuation of our conversation from previous episode with Dr. Sue Anne Toh, Co-Founder and Director of NOVI, we dive deeper into what happens when the drivers of metabolism go off track - leading to metabolic dysfunction. We explore how factors like body composition, insulin resistance, and chronic inflammation contribute to metabolic syndrome, particularly in South Asian populations. Dr. Toh shares insights on how wearable devices can empower individuals to understand their physiology and make meaningful behaviour changes.We also cover practical ways to improve gut health and rapid-fire round tackling common metabolism myths and facts.Time stamps:01:40 - Introduction Sue Anne 03:36 - Drivers of metabolism and metabolic syndrome 06:32 - Indicators of metabolic distress 10:53 - HbA1c marker16:14 - Inflammation on metabolism 24:38 - Inflammation marker threshold27:05 - Skinny fat cannot be eyeball, how to triage – Asian population 31:07 - Metabolic markers-Indian 32:24 - Supplements to delay metabolic distress onset 35:58 - Local nutraceuticals36:57 - Sequencing order of food40:58 - Time restricted eating44:30 - Wearables in managing health 55:04 - Negative gamification of wearable device57:02 - Convergence of health monitoring devices and AI58:47- Metabolic age01:00:00 - Exercise01:05:05 - Supplements for better gut health01:08:22 - Rapid fire- practical questions 01:16:46 - ClosingThe Guest: Dr. Sue Anne Toh is the Co-Founder, CEO and Medical Director of NOVI. She is also Adjunct Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore. Dr. Toh is a specialist in internal medicine, diabetes, endocrinology, and metabolism, with expertise in health systems, value-based healthcare, evidence-based wellness, integrated health services development, delivery, and evaluation.Connect with Dr. Sue Anne Toh: https://novi-health.com/ ,https://www.linkedin.com/in/sue-anne-toh-4225897/ References:1.https://clinicaltrials.gov/study/NCT02838693?term=NCT02838693&rank=12.Magkos F, Lee MH, Lim M, Cook AR, Chhay V, Loh TP, Chia KS, Baig S, Ang IYH, Tay JYY, Khoo CM, Halter JB, Toh SA. Dynamic assessment of insulin secretion and insulin resistance in Asians with prediabetes. Metabolism. 2022 Mar;128:154957. doi: 10.1016/j.metabol.2021.154957. Epub 2021 Dec 21. PMID: 34942192.3.Lee MH, Febriana E, Lim M, Baig S, Halter JB, Magkos F, Toh SA. Asian females without diabetes are protected from obesity-related dysregulation of glucose metabolism compared with males. Obesity (Silver Spring). 2023 Sep;31(9):2304-2314. doi: 10.1002/oby.23833. Epub 2023 Aug 3. PMID: 37534562.4.Lee MH, Febriana E, Lim M, Baig S, Shen L, Dalakoti M, Chew N, Loh TP, Chan M, Chia KS, Kong AP, Cook AR, Halter JB, Magkos F, Toh SA. Performance of the 1 h oral glucose tolerance test in predicting type 2 diabetes and association with impaired β-cell function in Asians: a national prospective cohort study. Lancet Reg Health West Pac. 2024 Dec 31;54:101278. doi: 10.1016/j.lanwpc.2024.101278. PMID: 39840148; PMCID: PMC11750441.About Biopeak: Biopeak is a deep science-led longevity organization focused on personalized, precise, predictive, and preventive healthcare. Built for South Asia, our approach blends cutting-edge diagnostics with systems science to craft personalised health plans. Biopeak helps you not just live longer—but live without limits. Biopeak. Decode your path to Limitless Living.Follow Us: Longevity India: https://www.longevity.iisc.ac.in/Biopeak: https://www.biopeak.com/LinkedIn: https://www.linkedin.com/company/longevity-india-iisc/Instagram: https://www.instagram.com/longevity_iisc/Spotify: https://open.spotify.com/show/0NXTdG0fBIfmKIHV2vkxbV