Episode 62: Drug Adherence and Persistence

Drug adherence and persistence measures built from claims or EHR databases depend as much on study definitions as recorded treatment events. In this QCast episode, co-hosts Jullia and Tom explain how adherence differs from persistence, what prescribing and dispensing data can and cannot show, and how MPR, PDC, treatment-gap rules and thresholds shape the findings.Key TakeawaysAdherence describes how closely medicine use follows the agreed regimen, while persistence measures how long treatment continues before discontinuation.Claims and EHR data provide useful evidence on prescriptions, dispensing and treatment changes, but neither confirms that a patient took the medicine as intended.MPR, PDC and persistence estimates depend on decisions about follow-up, days’ supply, permissible gaps, dose changes, switching and censoring.🔗 Learn More & Get Support: Visit quanticate.com to explore our biometrics services and discover how we can support your next clinical trial. 📝 Episode Notes & Transcript: Find show notes, resources, and a full transcript at quanticate.com/podcast.🔔 Stay Connected: Subscribe to QCast on Apple Podcasts, Spotify, or your favourite platform to never miss an episode.About QuanticateFounded in 1994, Quanticate is a biometrics-focused CRO with over 30 years' experience delivering expert clinical and post-marketing data services worldwide. Specialising in the collection, management, standardisation, analysis, and reporting of data, we support pharma and biotech companies globally with high-quality solutions for clinical development. We specialise in:Clinical Data Capture & ManagementBiostatistics & Statistical ConsultancyStatistical Programming & PK/PD AnalysisMedical Writing & PharmacovigilanceRegulatory & Submission SupportAI & AutomationPost-Marketing Safety & Real-World DataQuanticate is committed to delivering expertise and solutions that drive the success of clinical development worldwide.