Episode 65: Monoamine Oxidase Inhibitors and Psychoactive Drug Interactions

This week on The Tox Lab, we’re taking a closer look at monoamine oxidase inhibitors and their interactions with other substances.We begin by revisiting how MAOIs work and why inhibition of monoamine oxidase can create significant risks when combined with other drugs. Using a recent review paper as our guide, we explore reported interactions between MAOIs and commonly used psychoactive substances, and what this means for toxicity and clinical risk.We then turn to emerging research on the psychedelic compound APBT, examining its in vitro and in vivo metabolism and its activity as a potent monoamine oxidase inhibitor. This raises important questions about unrecognised MAOI activity in novel psychoactive substances and the potential for unexpected interactions.Join us as we unpack the pharmacology of MAO inhibition, interaction-driven toxicity, and what this evolving evidence means for clinical and forensic toxicology.Hope you enjoy!Links to the papers we discussed:https://pubmed.ncbi.nlm.nih.gov/41546846/ https://www.sciencedirect.com/science/article/abs/pii/S0300483X26000090?via%3Dihub Link to the article Rob mentioned: https://metro.co.uk/2018/05/16/brieing-is-the-new-cheese-and-mdma-drug-craze-middle-class-women-are-trying-7548127/Disclaimer: All opinions are our own.Find us on instagram: @the_tox_labEmail us here: [email protected]