Episode 66: CBD and Sleep – Clinical Evidence and Emerging Mechanisms

This week on The Tox Lab, we’re taking a closer look at CBD and its effects on sleep.CBD is widely marketed for insomnia and sleep disturbance, but what does the evidence actually show? In this episode, we begin by examining survey data demonstrating that some individuals report improvements in sleep with CBD use.We then unpack the pharmacology, focusing on CBD’s inhibition of adenosine uptake and how this may influence sleep regulation. We also discuss a randomised controlled trial investigating CBD in insomnia, highlighting findings that may contradict anecdotal evidence. Finally, we propose a mechanism through which CBD may be more beneficial for improving sleep in individuals who consume caffeine.Join us as we explore the intersection of pharmacology, perception, and clinical data, and consider what the current evidence really tells us about CBD and sleep.Hope you enjoy!Links to the papers we discussed:https://link.springer.com/article/10.1186/s42238-021-00061-5www.pnas.orgcgidoi10.1073pnas.0511232103 https://pmc.ncbi.nlm.nih.gov/articles/PMC11063694/Disclaimer: All opinions are our own.Find us on instagram: @the_tox_labEmail us here: [email protected]