Episode 7 Dr. Gabrielle Fredman "Resolution biology in the Vascular System:SPMs, Atherosclerosis, Plaque Stability & Cardiovascular Health"

Episode 7 Dr. Gabrielle Fredman "Resolution biology in the Vascular System:SPMs, Atherosclerosis, Plaque Stability & Cardiovascular Health"Welcome to the SPM Podcast, the podcastabout Specialized Pro-Resolving Mediators. Subscribe, leave a comment, and share thisepisode with anyone interested in heart health, inflammation resolution, and cutting-edgecardiovascular science. Episode Summary: In this compelling episode, we welcome Dr.Gabrielle Fredman, a leading researcher in inflammation resolution and vascular biology. Dr. Fredman explains how Specialized Pro-Resolving Mediators (SPMs) actively resolve.Specialized Pro-Resolving Mediators (SPMs) actively resolve chronic inflammation in blood vessels, promote the clearance of dead cells (efferocytosis), andhelp stabilize atherosclerotic plaques. The conversation dives into why atherosclerosisis fundamentally a disease of failed resolution, the imbalance between pro-inflammatory lipids and SPMs in plaques, and the therapeutic promise of boosting resolution pathways for cardiovascular disease.Guest Bio:Dr. Gabrielle Fredman, PhD, is a Professor in theDepartment of Molecular and Cellular Physiology at Albany Medical College in Albany, New York, where she leads the Fredman Lab. Dr Fredman's research focuses on themechanisms of inflammation resolution in atherosclerosis, vascular inflammation, aging, and plaque stability. She is particularly known for her work on how She is particularly known for her work on how Specialized Pro-Resolving Mediators (SPMs) such as resolvins regulate macrophage function, efferocytosis, and the transition from chronic inflammation to tissue repair in the cardiovascular system.Dr. Fredman has collaborated with SPM pioneers like Dr. Charles Serhan and has received NIH funding for her groundbreaking studies on resolution pharmacology in heart disease.Resources Mentioned:Key Papers: An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques. Nature Communications, 2016 https://www.nature.com/articles/ncomms12859Boosting inflammation resolution in atherosclerosis: the next frontier for therapy. The American Journal of Pathology, 2017 https://pmc.ncbi.nlm.nih.gov/articles/PMC5455064/ Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease.Nature Reviews Cardiology (with Charles Serhan), 2024 https://pmc.ncbi.nlm.nih.gov/articles/PMC12863063/ Resolvin D1 Enhances Necroptotic Cell Clearance and Promotes Plaque Stability Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 https://www.ahajournals.org/doi/10.1161/ATVBAHA.120.315758 Additional:Metagenics Institute Interview: The Role of Specialized Pro-Resolving Mediators in Atherosclerosis https://www.metagenicsinstitute.com/video/ spms-in-atherosclerosis/Fredman Profile at Albany Medical College https://www.amc.edu/researcher/gabrielle- fredman-phd/ Lab at Albany Medical College https://fredmanlab.com/