Episode 72 The Future of Doping Biological Passports and New Detectable Drugs 🧬

Episode 72 The Future of Doping Biological Passports and New Detectable Drugs 🧬💬 Got a question or feedback? Write us at: [email protected]☕ Buy a Gel Caf for Lactate to support the work: ko-fi.com/lactateSummary: The anti-doping arms race has reached a critical inflection point. Forget simply testing for drugs; the future is about tracking your unique biological footprint. This episode deciphers the Athlete Biological Passport (ABP), the revolutionary system that uses Bayesian statistical models to detect doping's secondary effects. We break down the mathematics of the OFF-score, explaining how it forensically distinguishes the abrupt hematological shifts of rhEPO micro-dosing from the gradual adaptations of altitude training. We also explore the cutting-edge science that has shattered the myth of "undetectable" gene doping, detailing how new assays like HiMDA can now identify CRISPR-Cas9 modifications in a tiny blood sample. For elite athletes, the 2026 WADA code brings massive changes. We provide a practical blueprint for navigating the new 60-minute post-exercise testing window, the strict prohibition on blood withdrawal without a TUE, and the career-ending risks of unregulated research peptides like BPC-157, which can be prosecuted through non-analytical evidence alone.Keywords: athlete biological passport, wada, doping, crispr, epo, micro-dosing, anti-doping, sports science, hif stabilizers🎙️ Lactate, the podcast that deciphers science to improve your performance.Key references :Yi, H., et al. (2025). High-throughput multiplexed gene and cell doping analysis through CRISPR-Cas12a system integrated with blood direct PCR. *Science Advances*. https://pmc.ncbi.nlm.nih.gov/articles/PMC12239944/AbuHaweeleh, M., et al. (2025). Integrating Advanced Metabolomics and Machine Learning for Anti-Doping in Human Athletes. *Metabolites*. https://www.mdpi.com/2218-1989/15/11/696Sottas, P. E., et al. (2018). A Bayesian Approach for the Use of Athlete Performance Data for Anti-Doping Purposes. *Frontiers in Physiology*. https://pmc.ncbi.nlm.nih.gov/articles/PMC6060570/Zorzoli, M., et al. (2021). Factors Confounding the Athlete Biological Passport: A Systematic Narrative Review. *Nutrients*. https://pmc.ncbi.nlm.nih.gov/articles/PMC8443715/World Anti-Doping Agency. (2026). *WADA publishes revised 2026 International Standard for Testing and Investigations with changes to blood collection wait times for Athletes*. WADA News. https://www.wada-ama.org/en/news/wada-publishes-revised-2026-international-standard-testing-and-investigations-changes-bloodVoices generated by artificial intelligence from the scientific report produced by the Lactate team.