Episode 75 - Exploring Non-Biologic Therapies for Hidradenitis Suppurativa from SF Derm Society 2024 Annual Meeting | The Future of Dermatology Podcast

Summary In this episode of the Future of Dermatology Podcast, we hear from Dr. Maria Aleshin who spoke at the Annual SF Derm Society's 2024 Meeting. She presents on Hidradenitis Suppurativa (HS) and various non-biologic treatment strategies. Dr. Aleshin covers practical approaches to managing HS flare-ups, long-term management considerations, and the role of antibiotics in treatment. She emphasizes the importance of personalized care and the need for a multifaceted approach to effectively address this challenging skin condition.   Takeaways The pathogenesis of HS is multifactorial, requiring a comprehensive treatment approach. Treatment stacking often involves combining medical, procedural, and lifestyle interventions. Topical therapies like chlorhexidine and benzoyl peroxide are commonly recommended, but alternatives exist. Systemic antibiotics are frequently used for managing HS flares. Hormonal therapies, including oral contraceptives and spironolactone, can be effective for female patients with HS. Metformin may be beneficial for patients with metabolic dysfunction associated with HS. Isotretinoin is not a first-line treatment for HS due to mixed results. Botulinum toxin can help reduce sweating and inflammation in HS patients. Combination antibiotic therapy, particularly clindamycin and rifampin, shows high efficacy but has relapse risks. Urtipenem is a powerful antibiotic reserved for severe HS cases as a bridge to surgery or biologics. Chapters 00:00 - Introduction to the Future of Dermatology Podcast 01:19 - Understanding Hidradenitis Suppurativa (HS) and Its Complexities 07:10 - Treatment Strategies for Managing HS Flare-Ups 10:21 - Long-Term Management of HS: Hormonal and Metabolic Considerations 13:20 - Antibiotic Therapies for Hidradenitis Suppurativa 17:22 - Severe HS Cases: Advanced Treatment Options and Considerations