Episode 80 - GATTTACA | In The Lab: Introduction to Molecular Haematology

from Bloody Minded · host Bloody Minded Crew

If we’re going to truly understand myeloid disease, we must dispense with the ward and journey to the dystopian heart that beats at the centre of each dysplastic cell. Learn what is valid and in-valid as we swim across an ocean of concepts - past the basic principles of DNA and RNA, Polymerase Chain Reaction and its many many variants, Fragment Analysis and Next Generation Sequencing. Just save a little something for the swim back to clinic next week.PS The Extra T is for TYOTT Timestamps0:55 - Back in the lab, baby!2:08 - Today's outline6:24 - What IS molecular testing?8:13 - The central dogma of molecular biology14:46 - Types of genetic mutations20:05 - Nomenclature for gene variants (advanced)23:52 - Samples for testing27:42 - What comes after DNA extraction30:11 - What is PCR and how did we discover it? 38:45 - What we do post PCR41:27 - Quantitative and RT-PCR 46:54 - Asking the RIGHT question48:55 - Digital droplet PCR50:44 - Electrophoresis52:35 - Fragment analysis and melt curve analysis54:33 - NGS1:00:02 - What is a VAF?1:05:23 - Lab governance (for haem ATs)1:09:32 - Take home messagesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Episode metadata supplied by the publisher feed · Published Mar 3, 2026

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Episode 80 - GATTTACA | In The Lab: Introduction to Molecular Haematology

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