Episode 82 - MDS 102 | Much More on Myelodysplastic Syndrome

Was episode 79 too light on MDS for you? “Amateurs” you said, adjusting your sellotaped glasses. If so, you’re in the right place today as we prepare to look at classification, risk stratification and treatment of myelodysplastic syndrome. You also should seek out psychiatric attention, or perhaps just go outside. But in the meantime, enjoy this episode where we’ll dig deeper into the nitty gritty of MDS! We’ve got a lot to cover so we float about between intermediate and advanced for this episode.TIMESTAMPS1:11 - A Very Unhinged Intro  3:34 - Actual Content Starts Here  5:52 - Differentials for dysplasia  7:54 - Presentations of MDS  12:36 - MDS Subtypes  14:23 - MDS with del(5q)  18:29 - Lenalidomide in del(5q)  25:03 - MDS with SF3B1  29:05 - MDS with biallelic TP53 inactivation  30:26 - Bonus cytogenetic abnormalities that pop up  31:43 - Germline mutations that predispose to MDS and AML  37:14 - MDS with low blasts  38:08 - Ogata Score  39:26 - Hypoplastic MDS  44:03 - MDS with increased blasts  44:58 - MDS with increased blasts and fibrosis  46:22 - Breaking News - Blasts Should Now Be Counted By Flow  48:30 - Prognostic models for MDS  53:36 - Treatments for MDS  1:04:39 - Take Home MessagesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au