Episode 88 - 1-2-3-4-5-6 | Blastic Plasmacytoid Dendritic Cell Neoplasm

Here’s a question, what do CD123, CD4 and CD56 have in common? Other than pleasing The Count on Sesame Street. Sorry, another question perhaps - what happens if you cross a plasma cell and a dendritic cell? The answers to these questions can be found on a most enigmatic myeloid cell - the plasmacytoid dendritic cell. And what happens when these rare beasts become neoplastic - why BPDCN of course. Embark on a journey into this weird and not so wonderful (but highly examinable) neoplasm with the Bloody Minded Crew TIMESTAMPS 0:57 – A glimpse into Cale's psyche 2:39 – Intro to BPDCN 6:56 – What IS a plasmacytoid dendritic cell? 10:24 – Pathological PDCs in BPDCN 11:42 – Clinical presentation – lots of rash talk 15:23 – Morphology in BPDCN 17:48 – Immunophenotype 21:16 – Karyotypic and molecular features 22:44 – Treatment of BPDCN 24:00 – A bit on prognostic markers 25:03 – Transplant 25:28 – Tagraxofusp 29:15 – Other treatment options 31:33 – Take home messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au