Episode 90: From Hopeless to Hopeful: An Integrative Approach to Depression with Dr. James Greenblatt episode artwork

EPISODE · Mar 3, 2026 · 49 MIN

Episode 90: From Hopeless to Hopeful: An Integrative Approach to Depression with Dr. James Greenblatt

from Uplift For Her · host Mallorie Cracroft, MD

Episode 90 - Dr. James Greenblatt, an internationally recognized pioneer in functional and integrative psychiatry, joins us for a second time to share a hopeful new perspective on treating depression.  Moving beyond the standard "anti-sad pill" model, Dr. Greenblatt explains why traditional treatments often fail the one-third of patients labeled as "treatment refractory" and how a deep dive into root causes, from nutritional deficiencies to hormonal imbalances, can offer a path toward true healing.In this episode, we explore the brain as a high-performance metabolic machine that requires a specific "fuel" of vitamins, minerals, and healthy fats to function optimally.  Dr. Greenblatt breaks down the essential labs every person struggling with depression should request, the truth about the gut-brain connection, and why women are particularly vulnerable to nutritional depletion during major hormonal transitions like postpartum and menopause. This is an empowering conversation designed to move you from feeling "numb" to feeling finally hopeful. Episode Resources: Book: Finally Hopeful: A Holistic Approach to Overcoming Depression Book: Finally Focused (for ADHD)  Clinic: FinallyLivingNow.com – Virtual functional psychiatry consultation program  Website: JamesGreenblattMD.com Podcast: Episode 68: Why ADHD in Women is So Often Misdiagnosed (And How to Finally Get Answers) with Dr. James Greenblatt Thanks for listening! Work with Uplift for Her and/or learn more about our offerings at upliftforher.com. Connect with us on Instagram and YouTube at @upliftforher. If this episode spoke to you, please take a moment to rate, review, or share it with someone who needs to hear it. Your support helps us reach more women with compassionate, evidence-based guidance on their path to wellness.   Support our podcast by using any of the following links & Uplift For Her discount codes:  Amazon Storefront: https://www.amazon.com/shop/upliftforher Coconu: Use code “upliftforher” at checkout for 15% off at coconu.com Fullscript Supplement Shop: https://us.fullscript.com/welcome/mcracroft Just Ingredients: Use code “upliftforher” for 10% off at https://justingredients.us/UPLIFTFORHER LumeBox: Save $250 with our link. Click here to shop Needed: 20% of your first order with our link. Click here to shop Saalt Period Products: Use code “UPLIFTFORHER20” for 20% off. Click here to shop  

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Episode 90: From Hopeless to Hopeful: An Integrative Approach to Depression with Dr. James Greenblatt

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This episode was published on March 3, 2026.

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Episode 90 - Dr. James Greenblatt, an internationally recognized pioneer in functional and integrative psychiatry, joins us for a second time to share a hopeful new perspective on treating depression.  Moving beyond the standard "anti-sad pill"...

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