Episode 91 - Have you tried turning it off and on again? | Allogeneic transplant in AML with Prof John Moore

Join us in our third straight week of incredibly nice and incredibly talented haematology gurus as Professor John Moore joins us as an expert guest to discuss stem cell transplant in the myeloid disease setting. TIMESTAMPS 1:00 – HYTTIOAOA 1:47 – Introducing Professor John Moore 8:06 – Advice to RMOs on the Allo Term 11:02 – The history of allogeneic transplantation 18:26 – Modern morbidity/mortality from alloSCT for AML 23:05 – Use of transplant scoring systems 27:29 – The role of MRD in transplant decisions 30:04 – MAC vs. RIC – Choice of Conditioning 38:15 – The role of PTCy 40:17 – Second allogeneic transplants 42:02 – DLI 43:08 – Biallelic TP53 – no good options 45:29 – Free rein in the trials space 49:11 – AlloSCT/CAR-T for autoimmune disease 55:05 – Take Home Messages Support the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au