Episode 93 - The Silmaril-IRON | Iron Metabolism

One molecule to rule them all, one molecule to find them. One molecule to bring them all, and in the liver bind them. Hepcidin is the key to understanding iron metabolism and we examine how iron gets into, around and out of the body. We promise not to be too Celebrimbor-ing as you join Nick, Cale and Bashar  for this discussion of the basic science of iron handling in preparation for our journey into the building blocks of blood. Welcome to Lord of the Haematinics. TIMESTAMPS0:56 - The next arc of the Bloody Minded Cinematic Universe3:23 - Series overview6:21 - Basic iron metabolism7:54 - The three main player groups in iron metabolism8:44 - Iron binding molecules: Heme13:22 - Non-heme iron14:05 - Iron binding molecules: Ferritin17:12 - Iron binding molecules: Transferrin20:44 - Iron transporters: DMT125:02 - Iron transporters: ferroportin28:21 - Iron transporters: Hephaestin29:28 - Iron flux33:24 - Hepcidin: Master Regulator and The One Ring39:04 - Non-hepcidin regulation of Ferroportin and IREs41:32 - Take home messagesSupport the showCheck out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au