Episode 21: Metabolic and genetic alterations in disease

In this episode, we examine how metabolic rewiring and genetic alterations drive cancer and neurological disease. We explore disrupted glycogen metabolism in rare neurodegenerative disorders, altered glucose utilization in leukemia, and the role of lipid metabolism in solid tumors. The conversation also highlights how key genetic mutations, such as those affecting TP53, reshape cellular pathways and disease progression. By examining these molecular changes across different diseases, we highlight how metabolism and genetics shape disease biology, revealing vulnerabilities that could be exploited for future therapeutic strategies."