European Journal of Pediatrics – Insights into Perinatal Management Episode Title: Navigating Trisomy 13 and 18: Balancing Prognosis with Dignity Host: Editor, European Journal of Pediatrics

This retrospective cohort study examines the clinical outcomes and management of 193 pregnancies affected by Trisomy 13 and 18 at a single medical center over an eighteen-year period. The research highlights a high rate of prenatal diagnosis and pregnancy termination, while documenting that among those who proceed to birth, survival times are short and highly unpredictable. Central to the text is the shift toward a multidisciplinary, family-centered approach that prioritizes palliative care over invasive surgical or life-prolonging interventions. Ultimately, the authors advocate individualized decision-making that balances the poor prognosis with the ethical imperative to maintain the newborn's comfort and dignity.