Everything about Alkaptonuria

It was a pleasure to be joined by the inimitable Professor Lakshminarayan Ranganath to discuss all things AKU. Ranga spoke about the outcomes of two recent papers looking at his centre’s experience using Nitisinone in these patients but also explains disease physiology, the history of drug discovery, new insights into the disease and upcoming research; 120 years of metabolic medicine in 25 minutes. Characterizing the alkaptonuria joint and spine phenotype and assessing the effect of homogentisic acid lowering therapy in a large cohort of 87 patients Lakshminarayan R. Ranganath, Milad Khedr, Sobhan Vinjamuri & James A. Gallagher https://doi.org/10.1002/jimd.12363 Characterising the arthroplasty in spondyloarthropathy in a large cohort of eighty‐seven patients with alkaptonuria Lakshminarayan R. Ranganath, James A. Gallagher, John Davidson & Sobhan Vinjamuri https://doi.org/10.1002/jimd.12340