Everything is a Signal: Sahir Ali on Connecting AI, Biology, and Venture Capital

Sahir Ali’s career defies conventional paths. Trained as an engineer, he worked in quantitative finance, contributed to cancer research, built software companies, and ultimately founded Modi Ventures, where he developed the BioStack investment framework for technology-driven life sciences.In this conversation with Sean Khozin, Sahir explains how systems thinking, mathematics, and first-principles reasoning shaped his approach to investing. They discuss the evolution of artificial intelligence in medicine, the realities of drug discovery, founder psychology, venture capital, and why enduring innovation often comes from connecting ideas across disciplines rather than following trends.