Evolving strategies in gynecologic cancer care

In this episode of the VJOncology podcast, we explore the evolving landscape of gynecologic cancer care with expert insights recorded at the 2025 ESMO Gynaecological Cancers Congress in Vienna. Ilana Cass, MD, Dartmouth-Hitchcock Medical Center, Lebanon, NH, discusses new data from the RUBY trial and the impact of dostarlimab in endometrial cancer. Christina Fotopoulou, MD, PhD, Imperial College London, London, UK, presents findings from the TRUST trial, highlighting the value of primary debulking surgery in advanced ovarian cancer. We also hear from Felix Hilpert, MD, Krankenhaus Jerusalem, Hamburg, Germany on overcoming treatment hesitancy in elderly ovarian cancer patients, and Angeles Secord, MD, Duke Cancer Institute, Durham, NC shares promising results from the PICCOLO study of mirvetuximab soravtansine in FRα-positive disease. Finally, Domenica Lorusso, MD, PhD, Fondazione IRCCS National Cancer Institute of Milan, Milan, Italy, outlines a new standard of care for stage 3 cervical cancer, combining radiotherapy with pembrolizumab as supported by KEYNOTE-A18. Tune in for expert commentary and clinical implications that could shape the future of gynecologic oncology.