Exercise protects and treats fatty liver with Dr John Thyfault

Dr Glenn McConell chats with Professor John Thyfault from the University of Kansas Medical Center. We discuss how when one takes in more calories than they expend, this results in elevated fat and glucose in the blood which disrupts liver metabolism. This can result in fatty liver and insulin resistance. Exercise can prevent and treat fatty liver even independently of body weight. There are important sex differences too. We also touch on ketones, carbohydrates, insulin and the liver. 0:00. Introduction and how got into exercise/liver research 6:48. Liver metabolism during exercise 8:17. Liver and insulin resistance 10:55. Why get fatty liver? 13:28. Liver very adaptable to diet and exercise 15:52. Converting carbohydrates into fats/lipids in the liver 17:03. Why some overweight get fatty liver and others not 18:23. How exercise prevents/treats fatty liver 21:26. Liver tries to compensate for fatty liver but eventually overwhelmed 22:50. Excess calories vs exercise Difference is turnover rate. 24:50. Liver as an energy converter 27:10. Liver uses fat for energy for new glucose production 28:15. What find of exercise to lower liver fat? 30:32. High fitness is protective of fatty liver 34:20. The body is very integrated across organs. 35:56. Energy balance and the liver 38:05. Can you outrun a bad diet? 40:40. Our dog makes an appearance! 40:46. How does the liver know we are exercising? 42:12. How does exercise make the liver more insulin sensitive? 42:44. Inactivity and the liver 44:11. Genetics/epigenetics 48:50. Sex differences and fatty liver 51:35. Translation of rodent studies to humans 54:09. Ketones, carbohydrates, insulin and the liver 58:10. Weight loss from calorie restriction vs exercise 59:09. Bile acid recycling and exercise capacity 1:02:04. Early life stress and obesity/running amount 1:04:10. Studies that worked out better than expected 1:07:26. Take home messages. 1:09:02. Outro (9 seconds) Inside Exercise brings to you the who's who of exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all. The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University. He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9). Connect with Inside Exercise and Glenn McConell at: Twitter: @Inside_exercise and @GlennMcConell1 Instagram: insideexercise Facebook: Glenn McConell LinkedIn: Glenn McConell https://www.linkedin.com/in/glenn-mcconell-83475460 ResearchGate: Glenn McConell Email: [email protected] Subscribe to Inside exercise: Spotify: https://open.spotify.com/show/3pSYnNSXDkNLH8rImzotgP?si=Whw_ThaERF6iIKwxutDoNA Apple Podcasts: https://podcastsconnect.apple.com/my-podcasts/show/inside-exercise/03a07373-888a-472b-bf7e-a0ff155209b2 Anchor YouTube Google Podcasts Podcast Addict etc