Exploring Learning-Induced Long Noncoding RNAs with Dr. Bredy: Junk DNA could be key to controlling fear

In this enlightening episode, we engage in a deep exploration of the role of long noncoding RNAs (lncRNAs) in learning processes, focusing particularly on fear-related learning, with Dr. Bredy. His breakthrough research has uncovered a substantial population of lncRNAs that respond in adult mice's infralimbic prefrontal cortex to fear-related learning.Dr. Bredy and his team used an advanced technique called RNA Capture-seq to identify these lncRNAs, supplementing these findings with cell-type-specific ATAC-seq applied to neurons selectively activated by fear extinction learning. Through this approach, they discovered 434 inducible lncRNAs that originate from enhancer regions near protein-coding genes.Among these lncRNAs, the team found an experience-induced lncRNA they named ADRAM (activity-dependent lncRNA associated with memory). ADRAM acts as a scaffold and a combinatorial guide, recruiting the brain-enriched chaperone protein 14-3-3 to the promoter of the memory-associated immediate-early gene Nr4a2. Notably, ADRAM is essential for the formation of fear extinction memory.This conversation with Dr. Bredy provides a wealth of information about the involvement of lncRNA activity in the brain, and the key role that enhancer-derived RNAs (eRNAs) play in the epigenomic regulation of gene expression related to the formation of fear extinction memory. Whether you're a neuroscientist, a geneticist, or anyone interested in the incredible complexity and capabilities of the brain, this episode will offer fresh insights and food for thought.https://doi.org/10.1016/j.celrep.2022.110546