Fact Sheet — Harnessing American AI to Unlock Cures for Pediatric Cancer

Fact Sheet — Harnessing American AI to Unlock Cures for Pediatric CancerKey Actions:MAHA Commission directed to:HHS to:Funding and Partnerships:Why it matters:Pediatric cancer is the leading cause of disease-related death for U.S. children; incidence has risen over 40% since 1975.AI can turn multi-omics and imaging data into new diagnostic, prognostic, and therapeutic biomarkers; improve predictive modeling; and enhance trial design, access, and outcomes.Context and prior steps:CCDI launched in 2019 to build a foundational national data infrastructure.Childhood Cancer STAR Act signed to bolster research, surveillance, and survivor support.2025 actions include: creating the MAHA Commission; releasing the Make Our Children Healthy Again Assessment; revitalizing the President’s Council on Sports, Fitness, and Nutrition (and the Presidential Fitness Test); publishing America’s AI Action Plan; and issuing the Make Our Children Healthy Again Strategy (120+ initiatives).Takeaway:This EO aligns federal policy, data infrastructure, and standards to accelerate AI-powered pediatric cancer research and care, aiming for faster diagnostics, better treatments, and improved outcomes while safeguarding patient privacy.