EPISODE · Nov 6, 2024 · 4 MIN
FAQ: Why is Binding CD64+ Important When Discussing IL23 Directed Therapy
from RhAPPcast
Join Heather Mambretti, PA-C, a rheumatology expert in Houston, Texas, and RhAPP member, as she explores the critical role of CD64-positive binding in IL-23 inhibition and its impact on autoimmune disease treatment.CD64, a high-affinity receptor expressed on myeloid lineage immune cells, plays a pivotal role in inflammatory signaling. IL-23, a key driver of inflammation in psoriatic arthritis, psoriasis, and inflammatory bowel disease, promotes pathogenic TH17 cell differentiation, contributing to chronic inflammation. Guselkumab (Tremfya) uniquely leverages a dual-binding mechanism, targeting both IL-23 and CD64-positive cells to enhance specificity and therapeutic efficacy.Insights from the DISCOVER-1 and DISCOVER-2 clinical trials highlight the benefits of IL-23 inhibition in psoriatic disease, demonstrating improved patient outcomes, reduced systemic inflammation, and minimized off-target effects.For more expert discussions on the latest advancements in rheumatology, visit RhAPP.org or explore the RhAPP ACE App.
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What this episode covers
Join Heather Mambretti, and a member of RhAPP, as she discusses the significance of CD64 positive binding in IL-23 directed therapy. In this video, Heather explains how targeting CD64 positive cells enhances the specificity and efficacy of IL-23 directed treatments, such as guselkumab, by delivering therapeutic agents directly to sites of inflammation.
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FAQ: Why is Binding CD64+ Important When Discussing IL23 Directed Therapy
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