EPISODE · Aug 1, 2025 · 8 MIN
FASTING: A 3 Organ Concert
from Metabolism Made Easy · host A J Ghalayini, Ph.D.
Maintenance of energy sources during fasting in the bloodstream depends on three organs acting in concert: 1. The liver which provides the bloodstream with glucose and ketone bodies; 2. Adipose tissue which provides the bloodstream with fatty acids; and 3. The muscle which provides lactate, alanine, and other amino acids as gluconeogenic precursors for glucose de novo synthesis in the liver. These actions are mostly controlled by a rise in both epinephrine and glucagon during fasting.
What this episode covers
Maintenance of energy sources during fasting in the bloodstream depends on three organs acting in concert: 1. The liver which provides the bloodstream with glucose and ketone bodies; 2. Adipose tissue which provides the bloodstream with fatty acids; and 3. The muscle which provides lactate, alanine, and other amino acids as gluconeogenic precursors for glucose de novo synthesis in the liver. These actions are mostly controlled by a rise in both epinephrine and glucagon during fasting.
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FASTING: A 3 Organ Concert
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