Fat Cell Recall: Why Losing Weight Isn’t the End of the Story

Why do people regain weight more quickly than expected after successfully losing it? Research shows that once someone has been overweight or obese, the genes in their fat cells undergo changes, creating a "memory" of the overweight state. This makes it easier for the body to return to that state. Listen in this week as Dee discusses this fascinating research, and what it means for long term weight loss maintenance.Reference:Hinte, L. C., Castellano-Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., Wolfrum, C., Rydén, M., Mejhert, N., Blüher, M., & Von Meyenn, F. (2024). Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature, (2024). https://www.nature.com/articles/s41586-024-08165-7