Skip to content
Fixing Healthcare's 528 Billion Dollar Mistake | with Chris Grilli episode artwork

EPISODE · Sep 3, 2025 · 59 MIN

Fixing Healthcare's 528 Billion Dollar Mistake | with Chris Grilli

from Self-Funded · host Spencer Smith

"We spend about $528 billion a year fixing the mistakes we make with medicines." - Chris Grilli Fixing healthcare's $528 billion dollar mistake starts with ending the "trial-and-error" prescribing that plagues our system. My guest this week, pharmacist and genomics expert Chris Grilli of RxMapper, joined the show to explain how personalized, DNA-guided medicine is the key to solving this massive problem. Chris breaks down the RxMapper model, explaining how they analyze 36 million data points from a patient's genome to provide medication recommendations with nearly 90% accuracy. We discuss the crucial difference between genetics and genomics, and how this approach saves thousands of dollars per patient while dramatically improving outcomes. The mission to fix this problem is also a personal one. Chris shared the story of how his grandmother's preventable death from an adverse drug event became the inspiration for building RxMapper to ensure other families don't suffer the same fate. Tune in this week for the playbook on fixing one healthcare's most expensive mistakes. Chapters: (00:00:00) Fixing Healthcare's $528 Billion Dollar Mistake (00:02:12) The $528 Billion Cost of Medication Errors (00:04:43) Genetics vs. Genomics: What's the Difference? (00:10:29) Are Doctors Prescribing "Poison?" (00:14:18) The Personal Story Behind RxMapper (00:27:17) Saving Over $8,600 Per Patient (00:41:24) How Your DNA Impacts Ozempic's Effectiveness Key Links for Social: @SelfFunded on YouTube for video versions of the podcast and much more - https://www.youtube.com/@SelfFunded Listen/watch on Spotify - https://open.spotify.com/show/1TjmrMrkIj0qSmlwAIevKA?si=068a389925474f02 Listen on Apple Podcasts - https://podcasts.apple.com/us/podcast/self-funded-with-spencer/id1566182286 Follow Spencer on LinkedIn - https://www.linkedin.com/in/spencer-smith-self-funded/ Follow Spencer on Instagram - https://www.instagram.com/selffundedwithspencer/

Episode metadata supplied by the publisher feed · Published Sep 3, 2025

Embed this episode

Ready to play

Fixing Healthcare's 528 Billion Dollar Mistake | with Chris Grilli

0:00 59:01

No transcript for this episode yet

We transcribe on demand. Request one and we'll notify you when it's ready — usually under 10 minutes.

No similar episodes found.

No similar podcasts found.

Frequently Asked Questions

How long is this episode of Self-Funded?

This episode is 59 minutes long.

When was this Self-Funded episode published?

This episode was published on September 3, 2025.

Can I download this Self-Funded episode?

Yes. Use the download control on the episode player to save the publisher-provided media file.
URL copied to clipboard!