Forgotten Infection Friday: Tranq Wounds- Xylazine Damage — When a Veterinary Sedative Destroys Human Tissue

This episode explains how xylazine ("tranq"), a veterinary sedative now found in the illicit drug supply, is causing severe, fast-progressing wounds and infections when mixed with fentanyl. It reviews the drug's vasoconstrictive effects, wound features (necrosis, deep infection, slow healing), key differences from diabetic foot ulcers, treatment priorities (debridement, antibiotics, advanced wound care), and the need for compassionate, comprehensive care and referral for substance use disorders.