Forskolin: The only natural molecule that directly activates adenylyl cyclase

Forskolin is the sole known natural direct activator of adenylyl cyclase the enzyme that produces cAMP (cyclic AMP), one of the most important second messengers in cell biology. cAMP activates everything from hormone-sensitive lipase (fat burning) to CFTR chloride channels (cystic fibrosis) to platelet inhibition. Pharma companies spend billions targeting cAMP pathways. Nature made one molecule that does it directly. It comes from an Indian root.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/12825829/https://pubmed.ncbi.nlm.nih.gov/6267587/https://pubmed.ncbi.nlm.nih.gov/22393824/