EPISODE · Oct 7, 2025 · 5 MIN
FOXP3 and the Peacekeepers: Unraveling Peripheral Immune Tolerance
from Intellectually Curious · host Mike Breault
From thymic education to the body’s last line of defense, this episode unpacks peripheral immune tolerance—the active backup that prevents autoimmunity and quiets benign exposures. We trace the Nobel-recognized discovery of FOXP3 and the master regulator role of regulatory T cells, outline the four intrinsic mechanisms that restrain self-reactive T cells, and explore the roles of tolerogenic dendritic cells and lymph node stromal cells. Join us as we discuss how these insights illuminate new therapeutic avenues for autoimmune disease and beyond, and reflect on what the 2025 Nobel work means for immunology.Note: This podcast was AI-generated, and sometimes AI can make mistakes. Please double-check any critical information.Sponsored by Embersilk LLC
Embed this episode
What this episode covers
From thymic education to the body’s last line of defense, this episode unpacks peripheral immune tolerance—the active backup that prevents autoimmunity and quiets benign exposures. We trace the Nobel-recognized discovery of FOXP3 and the master regulator role of regulatory T cells, outline the four intrinsic mechanisms that restrain self-reactive T cells, and explore the roles of tolerogenic dendritic cells and lymph node stromal cells. Join us as we discuss how these insights illuminate new ...
NOW PLAYING
FOXP3 and the Peacekeepers: Unraveling Peripheral Immune Tolerance
No transcript for this episode yet
Similar Episodes
No similar episodes found.
Similar Podcasts
No similar podcasts found.