EPISODE · Apr 20, 2026 · 5 MIN
Frankincense contains an antidepressant that crosses the blood-brain barrier
from NutraSift: The nutraceutical innovation podcast · host Siftlink SA
Incensole acetate, a compound found in boswellia resin (frankincense), activates TRPV3 ion channels in the brain and shows antidepressant and anxiolytic effects in animal models. It actually crosses the blood-brain barrier. Nobody in the supplement industry is talking about boswellia for mental health. Currently it is exclusively positioned for joints. The neuroinflammation angle is entirely virgin territory.Publications of interest:https://pubmed.ncbi.nlm.nih.gov/18492727/, https://pmc.ncbi.nlm.nih.gov/articles/PMC2493463/, https://pubmed.ncbi.nlm.nih.gov/23015543/
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Frankincense contains an antidepressant that crosses the blood-brain barrier
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