From Cross-Contamination to Cure: Hepatitis C

In this week's episode, we look into the history of Hepatitis C. The hepatitis C virus spread far and wide during the era before modern sterilization and screening, infecting millions. We look into the history, risks, symptoms (many have none!), and complications of hepatitis C. Finally, we look at how far treatment has progressed and what's coming up on the horizon.References:Khalili, M., & Burman, B. (2014). Liver disease. In Hammer, G. D., & McPhee, S. J. (Eds.). Pathophysiology Of Disease An Introduction To Clinical Medicine (7th ed., pp. 385-425). McGraw-Hill Education.https://archive.org/details/PathophysiologyOfDiseaseAnIntroductionToClinicalMedicine7thEdPDFtahir99VRG/page/410/mode/1up?view=theaterShiffman, M. (Ed.). (2012).  Chronic Hepatitis C Virus: Advances in Treatment, Promise for the Future. Springer Science+Business Media. DOI 10.1007/978-1-4614-1192-5_1 https://link.springer.com/book/10.1007/978-1-4614-1192-5Koren, M.J. & Kapila, N. (Hosts). (2025). The liver: Common causes of complications, cirrhosis, and cancer. [Podcast Episode]. In MedEvidence! Truth Behind the Data. MedEvidence. https://www.buzzsprout.com/1926091/episodes/17268919Rosen, H. R. (2011). Chronic hepatitis C infection. New England Journal of Medicine, 364(25), 2429-2438. https://www.nejm.org/doi/abs/10.1056/NEJMcp1006613Oancea, C. N., Butaru, A. E., Streba, C. T., Pirici, D., Rogoveanu, I., Diculescu, M. M., & Gheonea, D. I. (2021). Global hepatitis C elimination: history, evolution, revolutionary changes and barriers to overcome. Romanian Journal of Morphology and Embryology, 61(3), 643. https://pmc.ncbi.nlm.nih.gov/articles/PMC8112794/Good, S. S., Luo, S., Lin, K., Vo, A., Agrawal, N. G., & Sommadossi, J. P. (2025). Bemnifosbuvir and ruzasvir in combination exhibit potent synergistic antiviral activity in vitro while maintaining a favorable nonclinical safety profile in vivo. Antiviral Research, 237, 106137. https://www.sciencedirect.com/science/article/pii/S0166354225000634Share with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!