From Engineer to Rebel CEO: Jason Prestinario on Fighting for Patient Rights episode artwork

EPISODE · Jun 16, 2025 · 51 MIN

From Engineer to Rebel CEO: Jason Prestinario on Fighting for Patient Rights

from First Builders · host The Council

In this episode, we sit down with Jason Prestinario—Particle Health CEO of and former leader at Komodo Heath and Palantir Technologies —for a candid conversation about building in one of the most complex and regulated sectors in the world: healthcare. Jason talks about the difference between “product thinking” and “patient thinking,” why bundling in hospital systems leads to poor outcomes, and how startups can find leverage in a space dominated by incumbents.We also discuss the bold legal action Particle Health is taking against Epic Systems, and what it means to push for interoperability when it’s actively being blocked. This episode is a must-listen for anyone reimagining care delivery—or navigating systems designed to resist innovation.Follow Jason PrestinarioCompany: Particle HealthShow Notes:What Does HHS' RestructuringMean for Interoperability in Healthcare Epic Blocked over 420,000 Americans' Health Records from Doctors for Seven MonthsBook MentionedRange: Why Generalists Triumph in a Specialized World by David Epstein FOLLOW THE COUNCIL & FIRST BUILDERSNewsletterYouTube: @firstbuilderspodInstagram: @thecouncilcapitalTwitter/X: @first_builders_TikTok: @firstbuilderspodLinkedIn: The Council

Episode metadata supplied by the publisher feed · Published Jun 16, 2025

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In this episode, we sit down with Jason Prestinario—Particle Health CEO of and former leader at Komodo Heath and Palantir Technologies —for a candid conversation about building in one of the most complex and regulated sectors in the world: healthcare. Jason talks about the difference between “product thinking” and “patient thinking,” why bundling in hospital systems leads to poor outcomes, and how startups can find leverage in a space dominated by incumbents. We also discuss the bold legal ac...

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From Engineer to Rebel CEO: Jason Prestinario on Fighting for Patient Rights

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