From Hippocrates to Gene Therapy: The Journey of Diabetic Peripheral Arterial Disease

This episode of Diabetic Foot Files explores peripheral arterial disease (PAD) in people with diabetes — its history, how diabetes accelerates arterial damage, the biology behind impaired wound healing, and clinical clues to distinguish ischemic from neuropathic ulcers. We cover bedside tests (ABI, TBI, TcPO2), modern revascularization options, medical and lifestyle management, and emerging therapies, emphasizing early recognition and multidisciplinary care to improve limb salvage and outcomes.