From Salmon Sperm to Surgery: Cutting-Edge Regenerative Therapies

Oculoplastic Surgeon Linden Doss on PDRN, Microneedling, Lasers, Exosomes, and the Future of SurgeryDuncan Turner, MD interviews Santa Barbara oculoplastic surgeon Dr. Linden Doss about modern shifts from traditional cutting-and-lifting surgery toward regenerative approaches, including injectable PDRN (“salmon sperm”), placenta extract, microneedling, and selective laser resurfacing. Doss explains causes and treatment differences for under-eye dark circles, emphasizing thin skin and the roles of collagen versus elastin, and contrasts cold microneedling and pico lasers with heat-based devices that can damage elastin and promote scarring. They discuss scar-minimizing protocols after brow lifts, surgical precision in blepharoplasty, and why laser blepharoplasty is inferior to blades and needle-tip cautery. The conversation covers skepticism about fillers and “biostimulators,” evolving canthoplasty techniques, concerns and possibilities for robotic surgery, fat grafting challenges and nano-fat, the regulatory uncertainty around exosomes, and longevity/skin topics including rapamycin and antioxidants.00:00 Welcome and Introductions01:06 Why Eyes Matter in Menopause01:48 Regenerative Shift in Surgery04:15 Surgeon Culture and Cutting07:57 PDRN for Dark Circles13:20 Microneedling and Scar Blending16:21 Elastin Versus Heat Devices19:05 Pico Lasers and Resurfacing21:46 Placenta Extract Aftercare22:52 Robots and Surgical Tactile Skill31:24 Laser Bleph Limits34:00 Filler Fatigue and Healing37:41 Biostimulators and Muscle Devices41:56 Collagen and Elastin Supplements42:47 Marine Collagen Night Routine43:15 Elastin Supplements and Sourcing43:45 Heavy Metals in Supplements44:32 Peptides Versus Proteins44:53 EGF Myths and Wound Healing49:08 Placenta Extract for Healing50:28 Exosomes Basics and FDA Issues53:33 Exosomes in Real World Healing54:51 Fat Grafting Challenges and Cysts01:02:44 Nano Fat and Stem Cell Boost01:04:19 Measuring Eye Rejuvenation Outcomes01:05:45 Canthopexy and Fox Eye Surgery01:10:19 Rapamycin for Skin Longevity01:13:36 Eye Aging and Facial Hollowing01:15:39 Antioxidants for Retinal Health01:17:11 IV NAD and Glutathione Skepticism01:18:13 Closing Thoughts and Thanks