From Simulation to Scale: Rethinking Pharmaceutical Coating with Guest Dr. Michael Choi

Pharmaceutical manufacturing still struggles with a fundamental challenge: turning complex science into reliable, scalable, real-world processes. Dr. Michael Choi has spent his career solving exactly that. As Founder of PCTS and a pioneer in tablet coating simulation, Michael has developed tools that bring clarity to one of the most complex—and often misunderstood—steps in drug production. In this episode of Fractals: Life Science Conversations, Michael and host Colin Miller discuss: The hidden variability behind coating uniformity, and why probability sits at the core of the process How small, overlooked variables (like minor temperature shifts) can drive major manufacturing failures Why “more advanced” technology doesn’t always mean better outcomes without grounding in fundamentals The growing gap between sophisticated modelling tools and the teams who need them most How digital twins, continuous manufacturing, and AI could converge to transform production over the next decade At its core, this episode is about making science usable: bridging theory and execution to deliver better outcomes across the product lifecycle. Listen now on your preferred platform—and connect with Bracken to learn how we help translate complex science into actionable strategy.