Front Row: SABCS 2025 Insights with Dr. Francisco Esteva

Welcome to the first episode of 2026! Join host Victoria Goldberg in conversation with Dr. Francisco Esteva, a prominent board-certified medical oncologist specializing in the research and treatment of breast cancer, Chief of the Division of Hematology and Medical Oncology at Lenox Hill Hospital in New York, and Professor of Medicine at the Zucker School of Medicine at Hofstra/Northwell, as they dive deep into the groundbreaking research presented at the San Antonio Breast Cancer Symposium.In this comprehensive discussion, Dr. Esteva shares his expert insights on the latest advances transforming metastatic breast cancer treatment across all subtypes:HER2-Positive Disease:DESTINY-BREAST09 approval: trastuzumab deruxtecan plus pertuzumab as the new first-line standard with unprecedented 40-month progression-free survivalHER2CLIMB-05: Tukatinib's promise for preventing brain metastasesPATINA trial: Adding CDK4/6 inhibitors to maintenance therapyThe evolution from CLEOPATRA to combination approachesHormone Receptor-Positive Disease:Oral SERDs revolutionizing treatment: imlunestrant, elacestrant, and camizestrantSERENA-6 trial: Using liquid biopsies to detect ESR1 mutations and switch therapy before radiographic progressionPersonalized treatment strategies based on molecular profilingTriple-Negative Breast Cancer:Sacituzumab govitecan establishing itself as the preferred first-line optionCombining antibody drug conjugates with immunotherapyExpanding HER2-targeted therapy to HER2-low and HER2-ultralow patientsDr. Esteva also discusses the role of artificial intelligence in pathology, the importance of real-world evidence, and how treatment personalization is becoming the cornerstone of modern oncology. From his early work on trastuzumab and the PI3K pathway to today's cutting-edge ADCs, Dr. Esteva provides both historical context and forward-looking perspectives on where the field is headed.Whether you're a patient, caregiver, or healthcare professional, this episode offers valuable insights into how 2025 is shaping up to be a year of continued innovation and hope in metastatic breast cancer treatment.Disclaimer: This podcast is for educational purposes only and does not constitute medical advice. Always consult with your healthcare team about your specific treatment options.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.