Front Row Seat: Can We Talk about the Cure? A Conversation with Dr. Eric Winer

For a long time, the word "cure" and "metastatic breast cancer" didn't belong in the same sentence. That's changing — and nobody is better positioned to explain why than today's guest.Dr. Eric Winer is one of the world's leading breast cancer oncologists and researchers, former president of ASCO, and director of the Yale Cancer Center. In this conversation with Victoria Goldberg, he tackles the question he posed at the 2025 ABC8 conference in Lisbon: Can we talk about the cure?In this episode:Why HER2-positive metastatic breast cancer is the subtype closest to a cure — and what the biology tells usThe landmark trials rewriting the playbook: CLEOPATRA, PATINA, and DESTINY-Breast09 (DB-09)What "curative hope" means and how Dr. Winer talks about it with his own patientsThe truth about comparing DB-09 to CLEOPATRA — and why rushing to make Enhertu the universal first-line standard may be prematureOligometastatic disease, cancer dormancy, and surgery in the metastatic settingThe emerging science of exercise and cancer outcomes — and why it's no longer just about quality of lifeTwo groundbreaking curative-intent trials: SAPPHO (Dana Farber) and HERizon-Breast (Memorial Sloan Kettering, now open for enrollment), and what sequential therapy is actually trying to doThis is one of the most substantive, hopeful, and honest conversations we've had on Live from Stage IV — and one we've been waiting a long time to share.🔔 Subscribe so you never miss an episode. Leave us a review, visit our website, and follow us on social media to stay connected with the latest in metastatic breast cancer research.The information shared in this episode is for educational purposes only and does not constitute medical advice. Always consult your healthcare team about your individual treatment options.Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org for show notes and links. Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer.Until next time, take care and keep pushing for progress.