Future of Left Atrial Appendage Closure- ARCH presentation and discussion featuring Dr. Huded

In this MurmurMD discussion, Dr. Chetan Huded reviews the major trial data shaping modern LAA closure decision-making, including PROTECT AF, PREVAIL, PRAGUE-17, CLOSURE-AF, OPTION, and CHAMPION AF.The conversation focuses on the real clinical question facing physicians today:Can LAA closure match DOAC therapy for stroke prevention while reducing long-term bleeding risk?Key topics include:• LAA closure vs DOACs for stroke prevention• PROTECT AF, PREVAIL, PRAGUE-17, OPTION, CLOSURE-AF, and CHAMPION AF• Watchman FLX safety and modern outcomes• Amulet data and peri-device leak discussion• Stroke risk vs bleeding risk over time• Device-related thrombus and leak as ongoing concerns• Shared decision-making and patient selectionThis discussion breaks down the nuance behind the headlines and offers a practical framework for counseling patients considering appendage closure.🔔 Subscribe for more insights from interventional experts and real-world program builders.📱 Download the app: https://apps.apple.com/app/apple-store/id1586692687📺 Follow us on YouTube: https://www.youtube.com/channel/UCfrLYhAhliQ2ZvXinkDCZvAChapters:00:00 – Why LAA closure trials matter02:17 – DOACs: effective, but bleeding risk persists04:10 – Evolution of LAA closure devices05:10 – PROTECT AF, PREVAIL, and early Watchman data09:09 – Watchman FLX and improved procedural safety11:01 – Amulet IDE and next-generation data12:56 – LAAO vs DOACs: modern trial landscape13:41 – PRAGUE-17 and CLOSURE-AF16:53 – OPTION and CHAMPION AF20:03 – Why trial results may appear conflicting21:45 – Stroke, bleeding, DRT, and leak takeaways26:41 – Ablation, rhythm control, and combined strategies31:19 – Q&A: who should stay on medication?40:42 – Practical clinic takeaways49:31 – Risk buckets for shared decision-making54:45 – Final thoughts on patient selection#LAAO #LeftAtrialAppendageClosure #Watchman#WatchmanFLX #Amulet #DOAC#AtrialFibrillation #StrokePrevention#CHAMPIONAF #CLOSUREAF #OPTIONTrial#StructuralHeart #InterventionalCardiology #MurmurMD