EPISODE · Jul 26, 2026 · 13 MIN
高分综述：MASH的治疗靶点与个体化管理进展
from 消化肝病前沿资讯
本期播客聚焦代谢相关脂肪性肝炎（MASH）这一全球第一大慢性肝病，从疾病定义、发病机制切入，梳理生活方式干预、减重手术、肠促胰素、靶向药物等多元治疗方案，解析疾病异质性与三类致病表型，探讨个体化精准医疗与新兴靶点，展现MASH从病因入手的综合管理未来方向。00:06MASH成全球第一大肝病00:33代谢紊乱是致病核心源头01:34生活方式干预是基础治疗02:32减重手术带来显著肝脏获益03:17手术适应证已放宽调整04:16GLP-1类药物前景广阔05:14肠促胰素联合靶向药策略06:04疾病异质性与治疗分层06:36脂肪生成主导型表型解析07:19脂肪组织异常与遗传型08:07不同表型对应定制方案08:50FGF21类药逆转纤维化09:37DNL抑制剂与脱发副作用10:18DGAT2与PPAR激动剂进展11:15抗炎抗纤药临床遇瓶颈12:00新兴早期干预靶点盘点12:37个体化治疗成未来方向
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高分综述：MASH的治疗靶点与个体化管理进展
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