Gastro: Plummer-Vinson Syndrome: Free MSRA Podcast

⚕️FREE MSRA PODCAST –Plummer-Vinson Syndrome🎧 A rapid, high-yield revision covering the classical triad of Plummer-Vinson Syndrome (also known asPatterson-Kelly syndrome). Includes pathophysiology, presentation,investigations, and long-term cancer risk. 🧠Key Learning Points📌Definition• Plummer-VinsonSyndrome (PVS) is a rare conditiondefined by a classic triad:Iron-deficiency anaemiaOesophageal websGlossitis• Also referred to as Patterson-Kelly Syndrome 📌MnemonicA-Web-G• Anaemia• Oesophageal Webs• Glossitis 📌Causes• The exact cause ismultifactorial• Strongly linked tochronic iron deficiency• Associatedconditions:Coeliac diseaseInflammatory bowel diseasePernicious anaemiaThyroid disordersSjögren’s syndromeRheumatoid arthritis 📌Risk Factors• Chroniciron-deficiency• Poor nutritionalintake• Conditions causingmalabsorption• More common in middle-aged women, though becoming rarer in the UK 📌Pathophysiology• Chronic irondeficiency leads to mucosal changes inthe oesophagus• Results information of thin membranes (webs) thatcause dysphagia• The cellularmechanism is not fully understood 📌DifferentialDiagnosis• Simpleiron-deficiency anaemia without webs• Other causes of dysphagia: strictures, malignancy• Other causes of glossitis: vitamin B12 deficiency, candidiasis 📌Epidemiology• Rare in the UK,incidence is declining• More frequentlyseen in the Indian subcontinent• Previously morecommon in middle-aged women, but now alsoseen in men in some populations 📌Clinical Features• Symptoms:Fatigue, pallor, weakness (anaemia-related)Dysphagia (initially to solids)Weight lossGlobus sensation• Signs:PallorKoilonychia (spoon-shaped nails)Glossitis (smooth tongue)Angular cheilitisTachycardia 📌Diagnosis• Blood tests:FBC: microcytic, hypochromic anaemiaFerritin: low • Imaging:Barium swallow: shows oesophageal websOGD (endoscopy): confirms webs, allows for biopsy • Consider videofluoroscopy if dysphagia unclear 📌Management• Iron supplementation:Oral iron (e.g., ferrous sulfate)May require long-term treatment • Endoscopic surveillance (OGD):Regular monitoring due to malignancy risk• Interventions for persistent dysphagia:Endoscopic dilationArgon plasma coagulation for web destruction 📌Complications• Increased risk of squamous cell carcinoma of the oesophagus• Persistentdysphagia if untreated• Nutritionaldeficiencies 📎More MSRA Resourcesfor Plummer-Vinson Syndrome📝 Revision Notes:https://www.passthemsra.com/topic/plummer-vinson-syndrome-revision-notes/🧠 Flashcards:https://www.passthemsra.com/topic/plummer-vinson-syndrome-flashcards/💬 Accordion Q&A Notes:https://www.passthemsra.com/topic/plummer-vinson-syndrome-accordion-qa-notes/🚀 Rapid Quiz:https://www.passthemsra.com/topic/plummer-vinson-syndrome-rapid-quiz/🎓 Full Course:https://www.passthemsra.com/courses/gastroenterology-for-the-msra/ Hashtags#MSRA#MSRARevisionNotes #MSRATextbook #MSRAQuiz #MSRAQuestionBank #MSRAFlashcards#MSRAQ&ANotes #MSRAAccordions #MultiSpecialityRecruitmentAssessment#MSRAOnlineRevision #MSRARevisionWebsite #PlummerVinsonSyndrome