GLP-1 Agonist Pharmacology

The GLP-1’s are a relatively newer class of medications used to lower blood sugars in diabetes. GLP-1’s work by simulating the effects of incretin hormones in the body. They can help promote fullness, lower weight, and stimulate insulin release following a meal. GLP-1’s can cause significant GI side effects. Nausea is by far the most common adverse effect. It can even lead to diarrhea and vomiting in some cases. There is boxed warning on the GLP-1 agonists. Be aware of patients who have had a history of thyroid cancer as this may be a contraindication. GLP-1 agonists can help lower A1C and stimulate weight loss which is a huge benefit for most patients with Type 2 diabetes. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE!