GLP-1s, Weight and Exercise in MS

Maintaining a healthy weight may be particularly important in multiple sclerosis, as excess fat tissue can promote inflammation and contribute to other health conditions that may complicate MS. GLP-1 medications such as Ozempic and Mounjaro have transformed weight management, but could their benefits extend beyond weight loss? We explore emerging evidence that these medications may reduce inflammation, protect nerve cells, and possibly promote myelin repair, as well as clinical trials investigating their potential impact on MS progression. Exercise can also do much more than build muscle. We explore how targeted movement may harness neuroplasticity—the brain's ability to adapt and find new pathways around areas damaged by MS. Practical strategies are shared for improving fatigue, spasticity, core strength, balance, and mobility, even for people with significant disability. Barry Singer MD, Director of The MS Center for Innovations in Care, interviews: Olaf Stuve MD PhD, Professor of Neurology and Head of the Multiple Sclerosis and Neuroimmunology Section. UT Southwestern Medical Center, Dallas, Texas Trevor Wicken, Founder of The MS Gym, a global online platform for exercise and mindset training for people living with multiple sclerosis