Glycolysis: Allosteric Regulation of PFK-1

This podcast covers the allosteric regulation of Phosphofructokinase 1( PFK-1). A key allosteric activator is F2,6 bis-phosphate, which is produced by PFK-2 in the well-fed state. The production of this molecule is increased by the dephosphorylation of PFK-2, the enzyme responsible for its production. insulin will activate this enzyme by promoting g its dephodphorylation.Thus resulting in higher levels of F2, 6 bis-phosphate in the cytoplasm and resulting in the activation of PFK-1 and Glycolysis.