Goal – Deliver Cancer Drugs Faster: Dr. Marie-Agnès Doucey, Calico Biosystems

Do you know what is the % of cancer drug candidates that fail in human trials?Guess, and I bet you underestimated it.This is what we speak at the beginning of this episode and what my guest wants to change dramatically.You will also hear about:the % of patients that actually benefit from approved cancer drug therapies (spoiler: so so low)cancer monotherapies vs. cancer combination therapieshow to reproduce the human cancer ecosystem from a tumorprecision oncologymultiomics analysisand how to bring cancer drugs faster to patientsDr. Marie-Agnès Doucey, the co-founder of Calico Biosystems, is a biotechnology engineer with a PhD in biochemistry.  She has over 15 years of experience in R&D and drug development programs in oncology.Calico Biosystems is a Swiss startup developing a drug testing platform that uses patients’ tumors, multiomics profiling, and computational modeling to predict the clinical efficacy of anti-cancer drugs at the pre-clinical stage. Radically accelerating drug development.Here is their website:https://calicobiosystems.com/ 0:00 Dr. Marie-Agnès Doucey and Calico Biosystems1:15 Why Only 10% of Cancer Patients Benefit from Therapies9:00 Complexity of Experimental Oncology12:50 Cancer Monotherapies vs. Cancer Combination Therapies15:11 How to Reproduce Human Cancer Ecosystem17:10 What is Precision Oncology20:35 Platform for Cancer Drug Developers Instead of Animal Models32:34 Collaboration with the University of Lausanne37:49 What is Multiomics Analysis40:35 De-risking Clinical Studies and Moving to the Clinical Stage47:16 More Than a Decade of Research to Found a Startup53:07 Thank You, Follow Calico Biosystems53:55 Follow X-Health.show, Disclaimer If you've enjoyed listening, you'll make us happy by clicking "Follow" on X-Health.show and leaving a review.The information in this podcast is for informational purposes only and should not be considered medical advice. If you have any medical questions, please consult your healthcare practitioner. The opinions on the show are Alex's or her guests. The podcast does not make any responsibility or warranties about guests statements or credibility. While the podcast makes every effort to ensure that the information shared is accurate, please let us know if you have any comments, suggestions or corrections.