Gout Isn’t Purely a Problem Of Passing Purine

In this week's episode, we explore the stream of causes that can lead to the painful inflammatory condition gout. We look at the risks, progression, mechanics, and solutions available for this most common inflammatory arthritis. The primary cause of gout is excessive urate in the the blood depositing itself, especially toes. We then look ahead to clinical trials that recently wrapped up or are currently underway and which target the underlying urate in the blood or the immune response to urate crystals in joints.ReferencesDalbeth, N., Choi, H. K., Joosten, L. A., Khanna, P. P., Matsuo, H., Perez-Ruiz, F., & Stamp, L. K. (2019). Gout (primer). Nature Reviews. Disease Primers, 5(1).Chen-Xu, M. (2018, October). Contemporary prevalence of Gout and Hyperuricemia in the United States (National Health and Nutrition Examination Survey [NHANES] 2015-2016) and decadal trends (NHANES 2007-2016). In 2018 ACR/ARHP Annual Meeting. ACR. https://pmc.ncbi.nlm.nih.gov/articles/PMC6536335/ Benn, C. L., Dua, P., Gurrell, R., Loudon, P., Pike, A., Storer, R. I., & Vangjeli, C. (2018). Physiology of hyperuricemia and urate-lowering treatments. Frontiers in medicine, 5, 160. https://pmc.ncbi.nlm.nih.gov/articles/PMC5990632/Wu, C., Zhang, C., Jin, S., Wang, J. J., Dai, A., Xu, J., ... & Xu, H. E. (2025). Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs. Cell Discovery, 11(1), 33. https://pmc.ncbi.nlm.nih.gov/articles/PMC11962085/Rai, S. K., Fung, T. T., Lu, N., Keller, S. F., Curhan, G. C., & Choi, H. K. (2017). The Dietary Approaches to Stop Hypertension (DASH) diet, Western diet, and risk of gout in men: prospective cohort study. BMJ, 357. https://www.bmj.com/content/357/bmj.j1794.abstractKim, S. K. (2022). The mechanism of the NLRP3 inflammasome activation and pathogenic implication in the pathogenesis of gout. Journal of rheumatic diseases, 29(3), 140-153. https://synapse.koreamed.org/articles/1516078716Qaseem, A., Harris, R. P., Forciea, M. A., & Clinical Guidelines Committee of the American College of Physicians*. (2017). Management of acute and recurrent gout: a clinical practice guideline from the American College of Physicians. Annals of internal medicine, 166(1), 58-68. https://www.acpjournals.org/doi/full/10.7326/M16-0570Suo, Y., Fedor, J. G., Zhang, H., Tsolova, K., Shi, X., Sharma, K., ... & Lee, S. Y. (2025). Molecular basis of the urate transporter URAT1 inhibition by gout drugs. Nature Communications, 16(1), 5178. https://www.nature.com/articles/s41467-025-60480-3Atom Therapeutics. (2025, September 8). Atom therapeutics announces positive topline results of Lingdolinurad (ABP-671) in phase 2b/3 trial for chronic gout. [Website, accessed December 1, 2025]. https://www.businesswire.com/news/home/20250908760583/en/Atom-Therapeutics-Announces-Positive-Topline-Results-of-Lingdolinurad-ABP-671-in-Phase-2b3-Trial-for-Chronic-GoutShare with a friend. Rate, Review, and Subscribe to MedEvidence! Articles to be notified when new episodes are released.Follow us on Social Media:FacebookInstagramTwitterLinkedInTiktokYoutubeFor more great content, including discussions by physicians and clinical research experts, check out the MedEvidence! Podcast and MedEvidence.comThank you for listening!