Graft-Versus-Host Disease (GVHD)
from OrphaChat — a Rare Disease Podcast Hosted by RCH
These sources collectively examine graft-versus-host disease (GVHD), a serious complication of stem cell transplants where donor immune cells attack the recipient's body. The texts distinguish between acute and chronic forms, outlining diagnostic methods ranging from traditional histopathological biopsies to advanced biomarker algorithms like the MAGIC probability score. Significant attention is given to organ-specific manifestations, particularly in the skin, liver, and gastrointestinal tract, while highlighting the impact on long-term quality of life for survivors. The literature details a shift toward novel pharmacologic therapies, including FDA-approved agents such as ruxolitinib, belumosudil, and axatilimab for cases resistant to steroids. Additionally, clinical research explores preventative strategies using drugs like abatacept and vedolizumab to reduce disease incidence. Together, these documents provide a comprehensive framework for understanding the pathophysiology, clinical staging, and evolving treatment landscape of this condition.
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