GTG 73: Care of Women Presenting with Suspected PPROM from 24+0 Weeks of Gestation

This guideline comprises recommendations relating to the diagnosis, assessment, care and timing of birth of women presenting with suspected PPROM from 24+0 to 36+6 weeks of gestation. It also addresses care in a subsequent pregnancy. 1. Key recommendations (01:07) 2. Background and scope (03:35) 3. Identification and assessment of evidence (04:45) 4. Diagnosis (05:27) 4.1 How is the diagnosis of PPROM made? (05:30) 5. Assessment (10:54) 5.1 What is required antenatally to identify infection? (10:58) 5.2 Should neonatologists be included in the woman's care? (15:10) 6. Management (16:58) 6.1 Should antibiotics be given? (17:00) 6.2 What is the role of antenatal corticosteroids? (20:09) 6.3 What is the role of magnesium sulfate for neuroprotection of the baby? (25:30) 6.4 Should tocolytic agents be used? (28:17) 6.5 Can women be monitored at home? (30:22) 6.6 Is there a role for amnioinfusion in PPROM? (35:35) 6.7 Should women with PPROM be offered emotional support? (37:34) 7. Birth (39:02) 7.1 When is the appropriate time to deliver the baby? (39:05) 8. Care in a subsequent pregnancy following PPROM (44:26) 8.1 Who should care for a the woman in a subsequent pregnancy? (44:32) 9. Recommendations for future research (46:45) 10. Auditable topics (47:49) Disclosures of interest (49:18) Funding (49:35) Supporting information (50:13) References (51:03)