EPISODE · Feb 15, 2026 · 18 MIN
骨頭變脂肪的關鍵開關
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這份研究探討了骨髓間質幹細胞（BMMSCs）在分化為骨細胞或脂肪細胞過程中的分子調控機制。研究人員發現一種名為 Piezo1 的機械敏感離子通道，能透過抑制發炎反應來平衡骨量與脂肪。當缺乏 Piezo1 時，幹細胞會經由 Ccl2-Lcn2 訊號通路轉向產生脂肪，進而導致骨質疏鬆與骨髓脂肪堆積。實驗進一步證實，體育鍛煉產生的機械刺激必須依賴 Piezo1 才能發揮強化骨骼的效果。這項發現揭示了機械轉導與免疫調控之間的關聯，為開發預防骨骼衰老的治療策略提供了重要依據。 -- Hosting provided by SoundOn
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骨頭變脂肪的關鍵開關
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