Handbook of Essential Pharmacokinetics, Pharmacodynamics and Drug Metabolism for Industrial Scientists

A comprehensive overview of essential pharmacokinetics, focusing on the mathematical models and experimental methods used to study drug disposition in the body. The text systematically covers the disposition processes following both intravenous and oral administration, detailing topics such as sample collection, data interpretation using compartmental and noncompartmental approaches, and the estimation of key parameters like clearance, volume of distribution, and bioavailability. Furthermore, the material explores complex mechanisms including drug absorption kinetics, factors affecting bioavailability, protein binding, drug metabolism (especially involving Cytochrome P450 enzymes), biliary excretion, and nonlinear pharmacokinetics. The text also addresses advanced concepts like high-throughput screening, PK/PD relationships, and interspecies scaling for predicting human pharmacokinetics from in vitro and animal data.You can listen and download our episodes for free on more than 10 different platforms:https://linktr.ee/pharmacy_simpleProduced by:https://www.podcaistudio.com/