Hema Now: Advancing Care in Myelofibrosis

In this episode of Hema Now, we take a deep dive into myeloproliferative neoplasms (MPN), with a particular focus on myelofibrosis, one of the most complex and challenging MPNs to manage. Ciro Rinaldi discusses what distinguishes myelofibrosis from other chronic MPNs, the biological drivers of disease progression, and the critical role of inflammation and the bone marrow microenvironment. The conversation also explores emerging combination therapies, translational research hurdles, and how the management of myelofibrosis may evolve over the next decade. Timestamps:   00:00 – Introduction  00:59 – Myeloproliferative neoplasms  04:00 – Myelofibrosis  09:58 – Ciro's interest in the field  13:39 – Disease drivers & progression to aggressive states  17:40 – Inflammation and the bone marrow environment  22:19 – Novel targets  27:45 – Splenomegaly and MPNs  32:19 – Translational research  36:25 – Future of myelofibrosis management  38:51 – Ciro's three magic wishes