Hepatic Clearance: A key principle in anaesthesia

This primary FRCA podcast episode introduces clearance and then descends into bedlam trying to think about how the liver really clears drugs on a kinetics level. Shownotes @: https://gasgasgas.uk/hepatic-clearance/ I am not making you run for the hills by talking phase 1 and 2 metabolism, CYP and all that jazz, that's for a later episode. ================================================ GasGasGas - Covering Anaesthetic Science for Anaesthetists! Sponsored by Teach Me Anaesthetics Check out the Teach Me Anaesthetics 1100+ SBA Resource [affiliate] Contributions to keep the lamps lit here ================================================ Dr Gas Lurks On:  > BlueSky: Gas Gas Gas (@gasgasgaspodcast.bsky.social) > X / Twitter: GasGasGasFRCA (@GasGasGasFRCA) / X > FaceBook: Facebook - Gas Gas Gas > Website: www.gasgasgas.uk ================================================ Disclaimer / Sage Advice > All content is educational in nature and never intended to be acted upon. > This information is not a suitable substitute for medical advice. > Whilst the body of medical knowledge is slowly shifting and expanding, there are often differing numerics and notions for these core concepts, as such, accuracy of the content is not guaranteed.  > Where deemed sensible by the author, numerical ranges for technical data and references where reasonable will be present. ================================================ Music Credit: Streets of Sant Ivo - Mid-Air Machine - Free music archive  Sassy Jazzy - La Faena - Free music archive ================================================ "This podcast and all its content, including but not limited to audio recordings, show notes, artwork, and branding elements, are protected by copyright laws. All rights reserved. No part of this podcast may be reproduced, distributed, or transmitted without prior written permission from the copyright holder." © GasGasGas-Podcast 2025